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Factoid Details

‘An activation can be constitutive.’

[⟨det activation.n⟩ constitutive.a]

Learned by Reading

In the ICWSM 2009 Weblog Corpus:

Whole genome – microarray analyses suggest that these mutants cause constitutive activation of osmoregulatory signaling pathways.
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In Wikipedia:

Recently on other components of the Wnt signaling pathway have also demonstrated a likely role for constitutive activation of this pathway in the etiology of hepatoblastoma.
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In the ICWSM 2009 Weblog Corpus:

Constitutive activation of the RTK / RAS / MAPK causes all six VPCs to be activated resulting in a multivulva (Muv) phenotype.
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In the ICWSM 2009 Weblog Corpus:

RESULTS: It was found that constitutive activation of PSA expression was the result of sustained occupancy by the AR at the regulatory region of this gene.
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In the ICWSM 2009 Weblog Corpus:

Mutation of pry – 1 leads to constitutive activation of BAR – 1 / beta – catenin – dependent Wnt signaling and results in a range of developmental defects.
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In the ICWSM 2009 Weblog Corpus:

Constitutive activation of S6K in the MBH mimicked the effect of the HFD in normal chow? fed animals, while suppression of S6K by overexpression of dominant – negative S6K or dominant – negative raptor in the MBH restored the ability of MBH insulin to suppress HGP after HFD feeding.
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In the ICWSM 2009 Weblog Corpus:

Induction of cell adhesion correlated with cation – induced binding to ICAM – 1, clustering of LFA – 1 into lipid rafts and constitutive activation of the Rap1 and Rac1 GTPases.
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In the ICWSM 2009 Weblog Corpus:

We here describe that constitutive activation of the Stat5 – PI3K – Akt – cascade controls neoplastic MC development.
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In Wikipedia:

Phosphoinositide – 3 – kinase (PI – 3 – K) activates an important cell survival signaling pathway, and constitutive activation is seen in ovarian, head and neck, urinary tract, cervical and small cell lung cancer.
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In the ICWSM 2009 Weblog Corpus:

Glucose stimulates a 3 – fold increase in the rate of ChREBP nuclear entry, but trapping ChREBP in the nucleus by mutagenesis or with a nuclear export inhibitor does not lead to constitutive activation.
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In the ICWSM 2009 Weblog Corpus:

Constitutive activation of mitogen – activated protein kinase (MAPK) is a property common to many oncoproteins, including Mos, Ras, and Raf, and is essential for their transforming activities.
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In the ICWSM 2009 Weblog Corpus:

In small cell lung cancer (SCLC), non – small cell lung cancer (NSCLC), and malignant pleural mesothelioma (MPM), MET is dysregulated via overexpression, constitutive activation, gene amplification, ligand – dependent activation, mutation or epigenetic mechanisms.
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In the ICWSM 2009 Weblog Corpus:

Previous studies have demonstrated that mutations in cuticle collagens required for annular furrow formation (e. g., dpy – 2, 7, 8, and 10) and mutations in a group of non – collagen proteins that are thought to be secreted from the hypodermis to the cuticle (e. g., osm – 7, osm – 11, and osr – 1) cause constitutive activation of the glycerol accumulation pathway.
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In the ICWSM 2009 Weblog Corpus:

One, ga199, can affect wild – type vulval induction byitself and another, ga136, can suppress the Muv phenotype caused by constitutive activation of let – 60 ras.
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In the ICWSM 2009 Weblog Corpus:

Approximately 90 % of normal moles and 60 % of early invasive cutaneous melanomas contain a T1799A B – Raf mutation (V600EB – Raf), leading to 10 times higher enzyme activity and constitutive activation of the mitogen – activated protein kinase pathway.
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In the ICWSM 2009 Weblog Corpus:

The intrinsic GTPase activity of the alpha subunit is reduced by this mutation, presumably resulting in constitutive activation of its signal transduction pathway.
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In the ICWSM 2009 Weblog Corpus:

Stat3 – regulated factors produced by both tumor cells and tumor – derived myeloid cells also induced constitutive activation of Stat3 in tumor endothelium, and inhibiting Stat3 in ECs substantially reduced in vitro tumor factorinduced endothelial migration and tube formation.
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In the ICWSM 2009 Weblog Corpus:

Similarly, the constitutive activation of signaling cascades that stimulate cell growth has a profound impact on anabolic metabolism.
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In the ICWSM 2009 Weblog Corpus:

To identify genes encoding negative regulators of the glp – 1 signalling pathway, we screened for enhancer mutations that confer a tumorous phenotype in a sensitized glp – 1 genetic background, glp – 1 (oz112oz120). glp – 1 (oz112oz120) was identified as a cis intragenic revertant of glp – 1 (oz112gf), a novel glp – 1 (gf) mutation which results in constitutive activation of the glp – 1 (oz112gf) receptor.
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Queried on 2013-05-21.