Learned by Reading
In Wikipedia:
It has been suggested that SSRAs like MMAI and 4 – MTA could be developed as novel antidepressants with a faster onset of action and superior efficacy to current antidepressants such as the selective serotonin reuptake inhibitors (SSRIs).
(Parse)
(S1 (S (NP (PRP It))
(VP (AUX has)
(VP (AUX been)
(VP (VBN suggested)
(SBAR (IN that)
(S (NP (NP (NNS SSRAs))
(PP (IN like)
(NP (NP (NNP MMAI)) (CC and)
(NP (CD 4)))))
(: -)
(NP (NNP MTA))
(VP (MD could)
(VP (AUX be)
(VP (VBN developed)
(PP (IN as)
(NP (JJ novel) (NNS antidepressants)))
(PP (IN with)
(NP (NP (NP (DT a) (JJR faster) (NN onset))
(PP (IN of)
(NP (NN action))))
(CC and)
(NP (NP (JJ superior) (NN efficacy))
(PP (TO to)
(NP (NP (JJ current) (NNS antidepressants))
(PP (JJ such) (IN as)
(NP (NP (DT the) (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP SSRIs)) (-RRB- -RRB-)))))
(. .)))
In Wikipedia:
PDE5 – selective inhibitors may show good discrimination of PDE5 from most other PDE isoforms.
(Parse)
(S1 (FRAG (NP (NNP PDE5)) (: -)
(S (NP (JJ selective) (NNS inhibitors))
(VP (MD may)
(VP (VB show)
(NP (NP (JJ good) (NN discrimination))
(PP (IN of)
(NP (NP (NNS PDE5))
(PP (IN from)
(NP (JJS most) (JJ other) (NN PDE) (NNS isoforms)))
(. .)))
In the ICWSM 2009 Weblog Corpus:
Ssris b learn how this popular type of antidepressant works and about its side effects selective serotonin reuptake inhibitors (ssris) ssris are a type of antidepressant.
(Parse)
(S1 (S (NP (NNP Ssris) (NNP b))
(VP (VB learn)
(SBAR (WHADVP (WRB how))
(S (NP (NP (DT this) (JJ popular) (NN type))
(PP (IN of)
(NP (NP (JJ antidepressant) (NNS works)) (CC and)
(NP (RB about) (PRP$ its) (JJ side) (NNS effects)))))
(NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors) (-LRB- -LRB-) (NN ssris) (-RRB- -RRB-) (NNS ssris))
(VP (AUX are)
(NP (NP (DT a) (NN type))
(PP (IN of)
(NP (NN antidepressant)))))
(. .)))
In Wikipedia:
If medication is deemed necessary, the most commonly prescribed anti-depressants for this disorder are the selective serotonin reuptake inhibitors (SSRIs), which include fluoxetine (Prozac), sertraline (Zoloft), lexapro, paroxetine (Paxil), and citalopram (Celexa)..
(Parse)
(S1 (FRAG (SBAR (IN If)
(S (S (NP (NN medication))
(VP (AUX is)
(VP (VBN deemed)
(S (ADJP (JJ necessary)))
(, ,)
(NP (NP (DT the)
(ADJP (RBS most) (RB commonly) (VBN prescribed)) (NNS anti)) (: -)
(NP (NP (NNS depressants))
(PP (IN for)
(NP (DT this) (NN disorder)))))
(VP (AUX are)
(NP (NP (DT the) (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP SSRIs)) (-RRB- -RRB-)) (, ,)
(SBAR (WHNP (WDT which))
(S (VP (VBP include)
(NP (NP (NN fluoxetine)) (PRN (-LRB- -LRB-)
(NP (NNP Prozac)) (-RRB- -RRB-)) (, ,)
(NP (NN sertraline)) (PRN (-LRB- -LRB-)
(NP (NNP Zoloft)) (-RRB- -RRB-)) (, ,)
(NP (NN lexapro)) (, ,)
(NP (NP (NN paroxetine)) (PRN (-LRB- -LRB-)
(NP (NNP Paxil)) (-RRB- -RRB-)))
(, ,) (CC and)
(NP (JJ citalopram) (PRN (-LRB- -LRB-)
(NP (NNP Celexa)) (-RRB- -RRB-)) (NNS ..))))))))))))
In Wikipedia:
The autoreceptor – mediated inhibition of serotonin release has been hypothesized to be the reason for the delay seen in the therapeutic benefits of certain serotonergic antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs).
(Parse)
(S1 (FRAG (NP (DT The) (NN autoreceptor)) (: -)
(S (NP (NP (JJ mediated) (NN inhibition))
(PP (IN of)
(NP (JJ serotonin) (NN release))))
(VP (AUX has)
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(VP (VBN hypothesized)
(S (VP (TO to)
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(NP (NP (DT the) (NN reason))
(PP (IN for)
(NP (NP (DT the) (NN delay))
(VP (VBN seen)
(PP (IN in)
(NP (NP (DT the) (JJ therapeutic) (NNS benefits))
(PP (IN of)
(NP (NP (JJ certain) (JJ serotonergic) (NNS antidepressants))
(PP (JJ such) (IN as)
(NP (NP (NP (DT the) (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP SSRIs)) (-RRB- -RRB-)))
(CC and)
(NP (NP (JJ monoamine) (NN oxidase) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP MAOIs)) (-RRB- -RRB-)))))
(. .)))
In the ICWSM 2009 Weblog Corpus:
Medication Common medications used in depression treating are SSRIs (selective serotonin reuptake inhibitors).
(Parse)
(S1 (S (NP (NP (NN Medication) (JJ Common) (NNS medications))
(VP (VBN used)
(PP (IN in)
(NP (NN depression) (VBG treating)))))
(VP (AUX are)
(NP (NP (NNS SSRIs)) (PRN (-LRB- -LRB-)
(NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (-RRB- -RRB-))))
(. .)))
In Wikipedia:
PDE3 selective inhibitors.
(Parse)
(S1 (S (VP (VB PDE3)
(NP (JJ selective) (NNS inhibitors)))
(. .)))
In the ICWSM 2009 Weblog Corpus:
Strong evidence exists for the value of serotonergic drugs (e. g., selective serotonin reuptake inhibitors) in the treatment of ejaculation patients dissatisfied with paroxetine alone.
(Parse)
(S1 (S (NP (JJ Strong) (NN evidence))
(VP (VBZ exists)
(PP (IN for)
(NP (NP (DT the) (NN value))
(PP (IN of)
(NP (JJ serotonergic) (NNS drugs)))))
(PRN (-LRB- -LRB-)
(NP (NP (NNP e) (. .) (NNP g) (. .)) (, ,)
(NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)))
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(PP (IN in)
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(NP (NP (NN ejaculation) (NNS patients))
(VP (VBN dissatisfied)
(PP (IN with)
(NP (NP (NN paroxetine)) (ADVP (RB alone))))
(. .)))
In Wikipedia:
Medical interventions are primarily concerned with hormonal intervention and use of selective serotonin reuptake inhibitors (SSRIs).
(Parse)
(S1 (S (NP (JJ Medical) (NNS interventions))
(VP (AUX are) (ADVP (RB primarily))
(VP (VBN concerned)
(PP (IN with)
(NP (NP (JJ hormonal) (NN intervention)) (CC and)
(NP (NP (NN use))
(PP (IN of)
(NP (NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP SSRIs)) (-RRB- -RRB-)))
(. .)))
In Wikipedia:
Many tryptolines are competitive selective inhibitors of the enzyme monoamine oxidase type A (MAO – A). 5 – Hydroxytryptoline and 5 – methoxytryptoline are the most active monoamine oxidase inhibitors (MAOIs) with IC50s of 0.5 M and 1.5 M respectively, using 5 – hydroxytryptamine (serotonin) as substrate.
(Parse)
(S1 (S (NP (JJ Many) (NNS tryptolines))
(VP (AUX are)
(NP (NP (JJ competitive) (JJ selective) (NNS inhibitors))
(PP (IN of)
(NP (NP (DT the) (JJ enzyme) (JJ monoamine) (NN oxidase) (NN type))
(SBAR (S (NP (DT A) (PRN (-LRB- -LRB-)
(NP (NP (NNP MAO)) (: -)
(NP (DT A)) (-RRB- -RRB-) (. .) (CD 5)) (: -)
(NP (NNP Hydroxytryptoline) (CC and) (CD 5)) (: -)) (NN methoxytryptoline))
(VP (AUX are)
(NP (NP (DT the)
(ADJP (RBS most) (JJ active)) (JJ monoamine) (NN oxidase) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP MAOIs)) (-RRB- -RRB-))
(PP (IN with)
(NP (NP (NNS IC50s))
(PP (IN of)
(NP (NP (CD 0.5) (NNS M)) (CC and)
(NP (CD 1.5) (NNS M))))
(ADVP (RB respectively)) (, ,)
(S (VP (VBG using)
(NP (NP (CD 5)) (: -)
(NP (NP (NN hydroxytryptamine)) (PRN (-LRB- -LRB-)
(NP (NN serotonin)) (-RRB- -RRB-))))
(PP (IN as)
(NP (NN substrate)))
(. .)))
In Wikipedia:
Due to potentially lethal dietary and drug interactions, MAOIs had been reserved as a last line of defense, used only when other classes of antidepressant drugs (for example selective serotonin reuptake inhibitors and tricyclic antidepressants) have failed.
(Parse)
(S1 (S (PP (RB Due)
(PP (TO to)
(NP (ADJP (RB potentially) (JJ lethal)) (NN dietary) (CC and) (NN drug) (NNS interactions))))
(, ,)
(NP (NNP MAOIs))
(VP (AUX had)
(VP (AUX been)
(VP (VBN reserved)
(PP (IN as)
(NP (NP (DT a) (JJ last) (NN line))
(PP (IN of)
(NP (NP (NN defense)) (, ,)
(VP (VBN used)
(SBAR (WHADVP (RB only) (WRB when))
(S (NP (NP (JJ other) (NNS classes))
(PP (IN of)
(NP (NP (JJ antidepressant) (NNS drugs)) (PRN (-LRB- -LRB-)
(PP (IN for)
(NP (NN example)))
(NP (NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (CC and)
(NP (JJ tricyclic) (NNS antidepressants)))
(-RRB- -RRB-)))))
(VP (AUX have)
(VP (VBN failed))))
(. .)))
In the ICWSM 2009 Weblog Corpus:
In this review we address the question of the impact of anti-rheumatic drugs currently used in RA, such as non – steroidal anti-inflammatory drugs (e. g. non – selective or cyclooxygenase – 2 selective inhibitors), steroidal anti-inflammatory drugs (glucocorticoids), traditional disease – modifying anti-rheumatic drugs (e. g. methotrexate) or biologics (e. g. anti-tumour necrosis factor alpha anti-tumour necrosis factor alpha) on cardiovascular diseases in RA patients.
(Parse)
(S1 (S (PP (IN In)
(NP (DT this) (NN review)))
(NP (PRP we))
(VP (VB address)
(NP (NP (DT the) (NN question))
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(PP (IN of)
(NP (NP (JJ anti-rheumatic) (NNS drugs))
(VP (ADVP (RB currently)) (VBN used)
(PP (IN in)
(NP (NP (NNP RA)) (, ,) (FRAG (ADJP (JJ such)
(PP (IN as)
(NP (NN non))))
(: -)
(NP (JJ steroidal) (JJ anti-inflammatory) (NNS drugs)) (-LRB- -LRB-)
(VP (SYM e)) (. .)
(NP (NNP g)) (. .)
(NP (NN non)) (: -)
(ADJP (JJ selective) (CC or) (JJ cyclooxygenase)) (: -)
(NP (CD 2) (JJ selective) (NNS inhibitors)) (-RRB- -RRB-) (, ,)
(NP (NP (JJ steroidal) (JJ anti-inflammatory) (NNS drugs)) (PRN (-LRB- -LRB-)
(NP (NNS glucocorticoids)) (-RRB- -RRB-)))
(, ,)
(NP (JJ traditional) (NN disease)) (: -)
(S (VP (VBG modifying)
(NP (NP (NP (JJ anti-rheumatic) (NNS drugs)) (PRN (-LRB- -LRB-)
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(CC or)
(NP (NP (NNS biologics)) (PRN (-LRB- -LRB-) (FRAG (NP (NNP e)) (. .)
(NP (NNP g)) (. .)
(NP (NP (JJ anti-tumour) (NN necrosis) (NN factor) (NN alpha)) (JJ anti-tumour) (NN necrosis) (NN factor) (NN alpha)))
(-RRB- -RRB-))))
(PP (IN on)
(NP (JJ cardiovascular) (NNS diseases)))
(PP (IN in)
(NP (NNP RA) (NNS patients)))
(. .)))
In the ICWSM 2009 Weblog Corpus:
It focuses on strategies for marketing novel antidepressants (selective serotonin reuptake inhibitors, SSRIs) to doctors in Buenos Aires during the Argentine financial crisis of 2001, posing the question of whether increased antidepressant sales were due to the social situation or to promotional practices.
(Parse)
(S1 (S (NP (PRP It))
(VP (VBZ focuses)
(PP (IN on)
(NP (NP (NNS strategies))
(PP (IN for)
(S (VP (VBG marketing)
(NP (NP (JJ novel) (NNS antidepressants)) (PRN (-LRB- -LRB-)
(NP (NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (, ,)
(NP (NNP SSRIs)))
(-RRB- -RRB-)))
(PP (TO to)
(NP (NNS doctors)))
(PP (IN in)
(NP (NNP Buenos) (NNP Aires)))))
(PP (IN during)
(NP (NP (DT the) (JJ Argentine) (JJ financial) (NN crisis))
(PP (IN of)
(NP (CD 2001)))))
(, ,)
(S (VP (VBG posing)
(NP (NP (DT the) (NN question))
(PP (IN of)
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(VP (VBD were)
(ADJP (JJ due)
(PP (PP (TO to)
(NP (DT the) (JJ social) (NN situation)))
(CC or)
(PP (TO to)
(NP (JJ promotional) (NNS practices))))
(. .)))
In Wikipedia:
However, several of the new COX – 2 selective inhibitors have been recently withdrawn (see Vioxx), after evidence emerged that COX – 2 inhibitors increase the risk of heart attack.
(Parse)
(S1 (S (ADVP (RB However)) (, ,)
(NP (NP (NP (JJ several))
(PP (IN of)
(NP (DT the) (JJ new) (NNP COX))))
(: -)
(SBAR (S (NP (CD 2) (JJ selective) (NNS inhibitors))
(VP (AUX have)
(VP (AUX been)
(VP (ADVP (RB recently)) (VBN withdrawn) (PRN (-LRB- -LRB-)
(S (VP (VB see)
(NP (NNP Vioxx))))
(-RRB- -RRB-)) (, ,)
(SBAR (IN after)
(S (NP (NN evidence))
(VP (VBD emerged)
(NP (DT that) (NNP COX))))
(: -)
(NP (CD 2) (NNS inhibitors)))
(VP (VBP increase)
(NP (NP (DT the) (NN risk))
(PP (IN of)
(NP (NN heart) (NN attack)))))
(. .)))
In Wikipedia:
The selective serotonin reuptake inhibitors (SSRIs) such as sertraline (Zoloft) and paroxetine (Paxil), serotonin – norepinephrine reuptake inhibitors such as venlafaxine (Effexor), and bupropion (Wellbutrin), a norepinephrine and dopamine reuptake inhibitor, are the most common first – line drugs used to treat major depression.
(Parse)
(S1 (S (S (NP (NP (NP (DT The) (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (PRN (-LRB- -LRB-)
(NP (NNP SSRIs)) (-RRB- -RRB-))
(ADJP (ADJP (JJ such)
(PP (IN as)
(NP (NP (NP (NN sertraline)) (PRN (-LRB- -LRB-)
(NP (NNP Zoloft)) (-RRB- -RRB-)) (CC and)
(NP (NN paroxetine)) (PRN (-LRB- -LRB-)
(NP (NNP Paxil)) (-RRB- -RRB-)) (, ,)
(NP (NN serotonin)))
(: -)
(NP (NP (JJ norepinephrine) (JJ reuptake) (NNS inhibitors))
(PP (JJ such) (IN as)
(NP (NN venlafaxine)))
(PRN (-LRB- -LRB-)
(NP (NNP Effexor)) (-RRB- -RRB-)))
(, ,) (CC and) (NN bupropion)))
(PRN (-LRB- -LRB-)
(NP (NNP Wellbutrin)) (-RRB- -RRB-)) (, ,)
(NP (NP (DT a) (NN norepinephrine)) (CC and)
(NP (JJ dopamine) (JJ reuptake) (NN inhibitor)))
(, ,))
(VP (AUX are)
(NP (DT the)
(ADJP (RBS most) (JJ common)) (JJ first))))
(: -)
(S (NP (NN line) (NNS drugs))
(VP (VBD used)
(S (VP (TO to)
(VP (VB treat)
(NP (JJ major) (NN depression))))
(. .)))
In Wikipedia:
The term “Third generation antidepressant” is sometimes used to refer to even newer antidepressants, often selective serotonin reuptake inhibitors, such as fluoxetine, reboxetine, mirtazapine, nefazodone, paroxetine, sertraline, and venlafaxine.
(Parse)
(S1 (S (NP (DT The) (NN term) ('' '') (JJ Third) (NN generation) (NN antidepressant)) ('' '')
(VP (AUX is) (ADVP (RB sometimes))
(VP (VBN used)
(S (VP (TO to)
(VP (VB refer)
(PP (TO to)
(NP (NP (ADJP (RB even) (JJR newer)) (NNS antidepressants)) (, ,) (RB often)
(NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors)) (, ,)
(PP (JJ such) (IN as)
(NP (NN fluoxetine) (, ,) (NN reboxetine) (, ,) (NN mirtazapine) (, ,) (NN nefazodone) (, ,) (NN paroxetine) (, ,) (NN sertraline) (, ,) (CC and) (NN venlafaxine))))
(. .)))
In the ICWSM 2009 Weblog Corpus:
In addition to selective serotonin reuptake inhibitors like zoloft, prozac and paxil drop in blood pressure caused by a re – exposure to a foreign protein or a second dosage..
(Parse)
(S1 (S (PP (IN In)
(NP (NP (NN addition))
(PP (TO to)
(NP (NP (JJ selective) (JJ serotonin) (JJ reuptake) (NNS inhibitors))
(PP (IN like)
(NP (NNP zoloft) (, ,) (NNP prozac) (CC and) (NNP paxil))))
(VP (VB drop)
(PP (IN in)
(NP (NP (NP (NN blood) (NN pressure))
(VP (VBN caused)
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(: -)
(NP (NP (NN exposure))
(PP (TO to)
(NP (DT a) (JJ foreign) (NN protein))))
(CC or)
(NP (DT a) (JJ second) (NN dosage))))
(. .)) (. .)))
In Wikipedia:
While there is some evidence that anti-depressant pharmacotherapy with selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) may be effective in treating PMD, patients with PMD often do not respond to monotherapy and require a combination of anti-depressant and anti-psychotic medication.
(Parse)
(S1 (S (SBAR (IN While)
(S (NP (EX there))
(VP (AUX is)
(NP (DT some) (NN evidence)
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(S (NP (NP (NNS anti)) (: -)
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(NP (NNP SSRIs)) (-RRB- -RRB-)))
(CC and)
(NP (NP (JJ tricyclic) (NNS antidepressants)) (PRN (-LRB- -LRB-)
(NP (NNP TCAs)) (-RRB- -RRB-))))
(VP (MD may)
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(, ,)
(NP (NP (NNS patients))
(PP (IN with)
(NP (NNP PMD))))
(ADVP (RB often))
(VP (AUX do) (RB not)
(VP (VB respond)
(S (VP (TO to)
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(NP (NP (DT a) (NN combination))
(PP (IN of)
(NP (NP (NNS anti)) (: -)
(NP (NN depressant) (CC and) (NNS anti)) (: -)
(NP (JJ psychotic) (NN medication))))
(. .)))
In the ICWSM 2009 Weblog Corpus:
The amplitude of I CCh was reduced by pretreatment either with W – 7, trifluoroperazine, W – 5, and melittin (CaM inhibitors) or with ML – 7 and ML – 9 (selective MLCK inhibitors), and the inhibitory effects were reversible.
(Parse)
(S1 (S (S (NP (NP (DT The) (NN amplitude))
(PP (IN of)
(NP (NP (PRP I)) (NNP CCh))))
(VP (AUX was)
(VP (VBN reduced)
(PP (IN by)
(NP (NN pretreatment)))
(PP (DT either)
(PP (IN with)
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(NP (NNP trifluoroperazine)) (, ,)
(NP (NNP W) (: -) (CD 5)) (, ,) (CC and)
(NP (NP (NNP melittin)) (PRN (-LRB- -LRB-)
(NP (NNP CaM) (NNS inhibitors)) (-RRB- -RRB-)))))
(CC or)
(PP (IN with)
(NP (NP (CD ML)) (: -)
(NP (CD 7) (CC and) (CD ML)) (: -)
(NP (NP (CD 9)) (PRN (-LRB- -LRB-)
(NP (JJ selective) (NNP MLCK) (NNS inhibitors)) (-RRB- -RRB-)))
(, ,) (CC and)
(S (NP (DT the) (JJ inhibitory) (NNS effects))
(VP (AUX were)
(ADJP (JJ reversible))))
(. .)))
And 232 more sentences.