Systematic review can be constituted-of-or-filled-with randomized controlled trials.
Room can be for improvement of a quality of a design of randomized clinical trials.
Validity of systematic reviews may depend on a quality of randomized controlled trials.
A reporting of randomized controlled trials may be standardised.
Randomized controlled trials can be constituted-of-or-filled-with pharmacological agents.
Some issues may be related to a quality assessment of reports of randomized controlled trials.
A quality of a design of randomized clinical trials may be improved.
A quality of a design of randomized clinical trials may undergo an improvement.